A Pediatric B Lineage Leukemia With Coincident MYC and MLL Translocations.
Meeker, Nathan D. MD *,+; Cherry, Athena M. PhD ++,[S]; Bangs, Charles D. [S]; Frazer, John Kimble MD, PhD *,[//]
[Article] Journal of Pediatric Hematology/Oncology. 33(2):158-160, March 2011.

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Translocations are key oncogenic events, and many rearrangements are characteristic for a specific malignancy. We present here a case of phenotypic precursor-B acute lymphoblastic leukemia (ALL), subsequently found to have both MYC and MLL translocations. Owing to the potential prognostic impact of these translocations, a novel treatment strategy was applied which merged precursor-B ALL, Burkitt-ALL, and "MLL-adapted" rationales. With the advent of expanding diagnostic panels and molecular therapeutic options, use of such adapted therapies for individualized treatment will undoubtedly continue to increase as we move toward pharmacogenomic-based approaches.

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