Iatrogenic Botulism Due to Therapeutic Botulinum Toxin A Injection in a Pediatric Patient.
Crowner, Beth E. PT, DPT *; Brunstrom, Janice E. MD +; Racette, Brad A. MD +++
[Report] Clinical Neuropharmacology. 30(5):310-313, September/October 2007.

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Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.

(C) 2007 Lippincott Williams & Wilkins, Inc.