Polymorphisms in interferon regulatory factor 7 reduce interferon-[alpha] responses of plasmacytoid dendritic cells to HIV-1.
Chang, Judy a; Lindsay, Robert J a; Kulkarni, Smita b; Lifson, Jeffrey D c; Carrington, Mary a,b; Altfeld, Marcus a
25(5):715-717, March 13, 2011.
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Recognition of HIV-1 ssRNA by Toll-like receptor 7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here, we describe a novel association between polymorphisms in interferon regulatory factor 7 (IRF7), a master regulator of interferon-[alpha] (IFN-[alpha]), and the ability of plasmacytoid dendritic cells to produce IFN-[alpha] in response to HIV-1. IRF7 polymorphisms may, therefore, affect the ability of individuals to respond to HIV-1 and modulate HIV-1 disease progression.
(C) 2011 Lippincott Williams & Wilkins, Inc.